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The importance of conjugation in biliary secretion of ursodeoxycholate and 7-ketolithocholate in the rat.

Authors
Type
Published Article
Journal
Clinical science (London, England : 1979)
Publication Date
Volume
66
Issue
4
Pages
487–491
Identifiers
PMID: 6697665
Source
Medline
License
Unknown

Abstract

The biliary maximum secretory rate (SRmax.) of glycoursodeoxycholate in the bile fistula anaesthetized rat was about five times that of unconjugated ursodeoxycholate. Likewise, the biliary SRmax. of tauro-7-ketolithocholate was more than three times that of unconjugated 7-ketolithocholate. The SRmax. of 7-ketolithocholate infused with taurine (to avoid depletion of the taurine pool) was still significantly lower than that of exogenous tauro-7-ketolithocholate. These data support the hypothesis that, for bile acids that are poorly water soluble, the maximal biliary secretion rate is dependent on conjugating capacity, which is the limiting step in the overall transport from plasma into bile.

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