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Importance of Apolipoprotein A-I and A-II Composition in HDL and Its Potential for Studying COVID-19 and SARS-CoV-2

Authors
  • cho, kyung-hyun
Publication Date
Jul 16, 2021
Identifiers
DOI: 10.3390/medicines8070038
OAI: oai:mdpi.com:/2305-6320/8/7/38/
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

The composition and properties of apolipoprotein (apo) A-I and apoA-II in high-density lipoproteins (HDL) might be critical to SARS-CoV-2 infection via SR-BI and antiviral activity against COVID-19. HDL containing native apoA-I showed potent antiviral activity, while HDL containing glycated apoA-I or other apolipoproteins did not. However, there has been no report to elucidate the putative role of apoA-II in the antiviral activity of HDL.

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