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The importance of accounting for the uncertainty around the preference-based health-related quality-of-life measures value sets: a systematic review.

Authors
  • Kharroubi, Samer A1
  • Beyh, Yara1
  • 1 a Faculty of Agricultural and Food Science , American University of Beirut , Beirut , Lebanon. , (Lebanon)
Type
Published Article
Journal
Journal of medical economics
Publication Date
Jul 01, 2019
Volume
22
Issue
7
Pages
671–683
Identifiers
DOI: 10.1080/13696998.2019.1592178
PMID: 30841768
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Preference-based measures of health-related quality-of-life including, but not limited to, the EQ-5D, HUI2 and the SF-6D have been increasingly used in calculations of quality-adjusted life years for cost effectiveness analyses. However, the uncertainty around the measures' value sets is commonly ignored in economic evaluation. There are several types of uncertainties, including methodological, structural, and parameter uncertainties, with the latter being the focus of this review paper. The objective is to highlight the gap in the literature regarding the existence of uncertainty in the value sets, focusing mainly on the EQ-5D and SF-6D. To the best of the authors' knowledge, this is the first systematic review revolving around uncertainty. After searching extensively for studies involving uncertainties in all preference-based measures, the results showed that uncertainty has been approached through different means, while parameter uncertainty has been ignored in most, if not all, cases. These findings suggest that uncertainty should be accounted for when using preference-based measures in economic evaluations. Ignoring this additional information could impact misleadingly on policy decisions.

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