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The importance of accessory protein variants in the pathogenicity of SARS-CoV-2.

Authors
  • Hassan, Sk Sarif1
  • Choudhury, Pabitra Pal2
  • Dayhoff, Guy W 2nd3
  • Aljabali, Alaa A A4
  • Uhal, Bruce D5
  • Lundstrom, Kenneth6
  • Rezaei, Nima7
  • Pizzol, Damiano8
  • Adadi, Parise9
  • Lal, Amos10
  • Soares, Antonio11
  • Mohamed Abd El-Aziz, Tarek12
  • Brufsky, Adam M13
  • Azad, Gajendra Kumar14
  • Sherchan, Samendra P15
  • Baetas-da-Cruz, Wagner16
  • Takayama, Kazuo17
  • Serrano-Aroca, Ãngel18
  • Chauhan, Gaurav19
  • Palu, Giorgio20
  • And 10 more
  • 1 Department of Mathematics, Pingla Thana Mahavidyalaya, Maligram, 721140, India. Electronic address: [email protected]. , (India)
  • 2 Applied Statistics Unit, Indian Statistical Institute, Kolkata, 700108, West Bengal, India. , (India)
  • 3 Department of Chemistry, College of Art and Sciences, University of South Florida, Tampa, FL, 33620, USA.
  • 4 Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University-Faculty of Pharmacy, Irbid, 566, Jordan. , (Jordan)
  • 5 Department of Physiology, Michigan State University, East Lansing, MI, 48824, USA.
  • 6 PanTherapeutics, Rte de Lavaux 49, CH1095, Lutry, Switzerland. Electronic address: [email protected]. , (Switzerland)
  • 7 Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden. , (Iran)
  • 8 Italian Agency for Development Cooperation - Khartoum, Sudan Street 33, Al Amarat, Sudan. , (Sudan)
  • 9 Department of Food Science, University of Otago, Dunedin, 9054, New Zealand. , (New Zealand)
  • 10 Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
  • 11 Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, 78229-3900, USA.
  • 12 Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, 78229-3900, USA; Zoology Department, Faculty of Science, Minia University, El-Minia, 61519, Egypt. , (Egypt)
  • 13 University of Pittsburgh School of Medicine, Department of Medicine, Division of Hematology/Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
  • 14 Department of Zoology, Patna University, Patna, 800005, Bihar, India. , (India)
  • 15 Department of Environmental Health Sciences, Tulane University, New Orleans, LA, 70112, USA.
  • 16 Translational Laboratory in Molecular Physiology, Centre for Experimental Surgery, College of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. , (Brazil)
  • 17 Center for iPS Cell Research and Application, Kyoto University, Japan. , (Japan)
  • 18 Biomaterial and Bioengineering Lab, Translational Research Centre San Alberto Magno, Catholic University of Valencia San Vicente M'artir, c/Guillem de Castro 94, 46001, Valencia, Spain. , (Spain)
  • 19 School of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, 64849, Monterrey, Nuevo León, Mexico. , (Mexico)
  • 20 Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35121, Padova, Italy. , (Italy)
  • 21 University of Southern Denmark, Mads Clausen Institute, NanoSYD, Alsion 2, 6400, Sønderborg, Denmark. , (Denmark)
  • 22 Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, WB, India; Departamento de Genética, Ecologia e Evolucao, Instituto de Cîencias Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. , (Brazil)
  • 23 Departamento de Ciencias Biologicas (DCB), Programa de Pos-Graduacao em Genetica e Biologia Molecular (PPGGBM), Universidade Estadual de Santa Cruz (UESC), Rodovia Ilheus-Itabuna, km 16, 45662-900, Ilheus, BA, Brazil. , (Brazil)
  • 24 Laboratório de Bioinformática e Química Computacional, Departamento de Ciências Biológicas, Universidade Estadual do Sudoeste da Bahia (UESB), Jequié, 45206-190, Brazil. , (Brazil)
  • 25 Departamento de Genética, Ecologia e Evolucao, Instituto de Cîencias Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. , (Brazil)
  • 26 Laboratório de Biologia Molecular e Computacional de Fungos, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil. , (Brazil)
  • 27 Neuroscience Center of Excellence, School of Medicine, LSU Health New Orleans, New Orleans, LA, 70112, USA.
  • 28 King Abdulaz University, Faculty of Science, Department of Biological Science, Saudi Arabia. , (Saudi Arabia)
  • 29 School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK. , (Ireland)
  • 30 Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, 33612, USA; Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Institutskiy pereulok, 9, Dolgoprudny, 141700, Moscow region, Russia. Electronic address: [email protected].
Type
Published Article
Journal
Archives of Biochemistry and Biophysics
Publisher
Elsevier
Publication Date
Mar 15, 2022
Volume
717
Pages
109124–109124
Identifiers
DOI: 10.1016/j.abb.2022.109124
PMID: 35085577
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS- CoV-2) with an estimated fatality rate of less than 1%. The SARS-CoV-2 accessory proteins ORF3a, ORF6, ORF7a, ORF7b, ORF8, and ORF10 possess putative functions to manipulate host immune mechanisms. These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology. Outspread variations of each of the six accessory proteins were observed across six continents of all complete SARS-CoV-2 proteomes based on the data reported before November 2020. A decreasing order of percentage of unique variations in the accessory proteins was determined as ORF3a > ORF8 > ORF7a > ORF6 > ORF10 > ORF7b across all continents. The highest and lowest unique variations of ORF3a were observed in South America and Oceania, respectively. These findings suggest that the wide variations in accessory proteins seem to affect the pathogenicity of SARS-CoV-2. Copyright © 2022 Elsevier Inc. All rights reserved.

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