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Implications of Sex Differences in Immunity for SARS-CoV-2 Pathogenesis and Design of Therapeutic Interventions

Authors
  • Bunders, Madeleine J.1
  • Altfeld, Marcus1, 2
  • 1 Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
  • 2 Institute for Immunology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany
Type
Published Article
Journal
Immunity
Publication Date
Aug 17, 2020
Volume
53
Issue
3
Pages
487–495
Identifiers
DOI: 10.1016/j.immuni.2020.08.003
PMID: 32853545
PMCID: PMC7430299
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Unknown

Abstract

Clinical manifestations of SARS-CoV-2 infection differ between women and men, with men presenting more frequently with severe COVID-19. We review the impact of sex differences in immunity for these differences in COVID-19 and discuss the implications for clinical interventions.

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