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Implications of sequence variation on the evolution of rRNA

Authors
  • Parks, Matthew M.1
  • Kurylo, Chad M.1
  • Batchelder, Jake E.2
  • Theresa Vincent, C.1, 3
  • Blanchard, Scott C.1, 4
  • 1 Weill Cornell Medicine, Department of Physiology and Biophysics, New York, NY, USA , New York (United States)
  • 2 Weill Cornell Medicine, Department of Immunology, New York, NY, USA , New York (United States)
  • 3 Uppsala University, Department of Immunology, Genetics and Pathology, Uppsala, Sweden , Uppsala (Sweden)
  • 4 Weill Cornell Medicine, Tri-Institutional PhD Program in Chemical Biology, New York, NY, USA , New York (United States)
Type
Published Article
Journal
Chromosome Research
Publisher
Springer-Verlag
Publication Date
Feb 05, 2019
Volume
27
Issue
1-2
Pages
89–93
Identifiers
DOI: 10.1007/s10577-018-09602-w
Source
Springer Nature
Keywords
License
Green

Abstract

The evolution of the multi-copy family of ribosomal RNA (rRNA) genes is unique in regard to its genetics and genome evolution. Paradoxically, rRNA genes are highly homogenized within and between individuals, yet they are globally distinct between species. Here, we discuss the implications for models of rRNA gene evolution in light of our recent discoveries that ribosomes bearing rRNA sequence variants can affect gene expression and physiology and that intra-individual rRNA alleles exhibit both context- and tissue-specific expression.

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