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Implications of mitochondrial uncoupling in skeletal muscle in the development and treatment of obesity.

Authors
  • Thrush, A Brianne
  • Dent, Robert
  • McPherson, Ruth
  • Harper, Mary-Ellen
Type
Published Article
Journal
FEBS Journal
Publisher
Wiley (Blackwell Publishing)
Publication Date
Oct 01, 2013
Volume
280
Issue
20
Pages
5015–5029
Identifiers
DOI: 10.1111/febs.12399
PMID: 23786211
Source
Medline
Keywords
License
Unknown

Abstract

Understanding the metabolic factors that contribute to obesity development and weight loss success are critical for combating obesity and obesity-related disorders. This review provides an overview of energy metabolism with a particular focus on mitochondrial function in health and in obesity. Mitochondrial proton leak contributes significantly to whole body energy expenditure and the potential role of energy uncoupling in weight loss success is discussed. We provide evidence to support the hypothesis that differences in energy efficiency are important regulators of body weight and weight loss success.

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