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Implications of global and local mobility in amorphous sucrose and trehalose as determined by differential scanning calorimetry.

Authors
  • Dranca, Ion
  • Bhattacharya, Sisir
  • Vyazovkin, Sergey
  • Suryanarayanan, Raj
Type
Published Article
Journal
Pharmaceutical Research
Publisher
Springer-Verlag
Publication Date
May 01, 2009
Volume
26
Issue
5
Pages
1064–1072
Identifiers
DOI: 10.1007/s11095-008-9817-7
PMID: 19130185
Source
Medline
License
Unknown

Abstract

Trehalose, having a lower free volume in the glassy state due to a more tightly packed molecular structure, is characterized by larger activation energies of alpha-relaxation and experiences a greater effect of temperature on the reduction in the activation energy barrier for viscous flow. The pronounced increase in cooperative motions in sucrose upon annealing at temperatures below (T(g) -50) suggest that even a small excursion in temperature could result in a significant increase in mobility.

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