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Implications of gene networks for understanding resilience and vulnerability in the kidney branching program.

Authors
  • Sampogna, Rosemary V
  • Nigam, Sanjay K
Type
Published Article
Journal
Physiology (Bethesda, Md.)
Publication Date
Dec 01, 2004
Volume
19
Pages
339–347
Identifiers
PMID: 15546851
Source
Medline
License
Unknown

Abstract

Branching morphogenesis in the kidney is tightly regulated. Whereas disruption of certain pathways produces catastrophic effects, numerous instances exist in which mutation of ostensibly key molecules has minimal apparent phenotypic consequence. We suggest how the network structure of gene interactions in the branching program might explain these findings as well as apparant discrepancies between in vivo and in vitro studies. Emerging genetic, cell-biological, and microarray data should help test and/or clarify these ideas.

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