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Implication of protein kinase B/Akt and Bcl-2/Bcl-XL suppression by the farnesyl transferase inhibitor SCH66336 in apoptosis induction in squamous carcinoma cells.

Authors
  • Chun, Kyung-Hee
  • Lee, Ho-Young
  • Hassan, Khaled
  • Khuri, Fadlo
  • Hong, Waun Ki
  • Lotan, Reuben
Type
Published Article
Journal
Cancer research
Publication Date
Aug 15, 2003
Volume
63
Issue
16
Pages
4796–4800
Identifiers
PMID: 12941797
Source
Medline
License
Unknown

Abstract

The farnesyltransferase inhibitor SCH66336 exhibits antitumor activity in vitro and in vivo; however, its mechanism of action is still unresolved. We found that SCH66336 suppressed growth and induced apoptosis of human head and neck squamous carcinoma cells (HNSCC). SCH66336 suppressed protein kinase B/Akt activity as well as the phosphorylation of the Akt substrates glycogen synthase kinase (GSK)-3 beta, forkhead transcription factor, and BAD. Infection of SqCC/Y1 cells with an adenovirus that contained a constitutively active form of Akt rescued cells from SCH66336-induced apoptosis. These results suggest that SCH66336 is a potent apoptosis inducer in HNSCC cells and that it may act by suppressing the Akt pathway.

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