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Impairment of online control of hand and eye movements in a monkey model of optic ataxia.

Authors
  • Battaglia-Mayer, Alexandra1
  • Ferrari-Toniolo, Simone
  • Visco-Comandini, Federica
  • Archambault, Philippe S
  • Saberi-Moghadam, Sohrab
  • Caminiti, Roberto
  • 1 Department of Physiology and Pharmacology, SAPIENZA, University of Rome, Italy and. , (Italy)
Type
Published Article
Journal
Cerebral Cortex
Publisher
Oxford University Press
Publication Date
Nov 01, 2013
Volume
23
Issue
11
Pages
2644–2656
Identifiers
DOI: 10.1093/cercor/bhs250
PMID: 22918983
Source
Medline
Keywords
License
Unknown

Abstract

The parietal mechanisms for online control of hand trajectory were studied by combining single-cell recording and reversible inactivation of superior parietal area 5 (PE/PEc; SPL) of monkeys while these made reaches and saccades to visual targets, when the target position changed unexpectedly. Neural activity was modulated by hand position, speed, and movement direction, and by pre- and/or postsaccadic signals. After bilateral muscimol injection, an increase in the hand reaction- and movement-time toward both the first and second targets was observed. This caused an increase in the time necessary for the trajectory correction, and therefore an elongation of the hand-path toward the first target location. Furthermore, hand trajectories were different in shape than control ones. An elongation of the eye reaction time to both first and second targets was also observed, which could partially explain the deficit of planning and correction of hand movement. These results identify the superior parietal lobule as a crucial node in the online control of hand and eye movement and highlight the role of the eye impairment in the emergence of the reaching disorder so far regarded as the hallmark of optic ataxia.

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