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Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins.

Authors
  • Kugiyama, K
  • Kerns, S A
  • Morrisett, J D
  • Roberts, R
  • Henry, P D
Type
Published Article
Journal
Nature
Publication Date
Mar 08, 1990
Volume
344
Issue
6262
Pages
160–162
Identifiers
PMID: 2106627
Source
Medline
License
Unknown

Abstract

Atherosclerosis in animals and humans is associated with an unresponsiveness of arteries and arterioles to endothelium-dependent vasodilators--agents acting on smooth muscle indirectly by stimulating the release from endothelial cells of a vasodilator principle (endothelium-derived relaxing factor). Altered vasomotor regulation in atherosclerosis could partly reflect an injurious action of abnormal lipoproteins on endothelium. Recently, 'cell-modified' or 'oxidized' low-density lipoprotein (EC-LDL) has received increasing attention because of its potential cytotoxic and atherogenic properties. We report here that arteries exposed to EC-LDL in vitro show an endothelium-dependent vasoregulatory impairment closely resembling that of atherosclerotic arteries. Our results indicate that transfer of lysolecithin from EC-LDL to endothelial membranes produces a selective unresponsiveness to receptor-regulated endothelium-dependent vasodilators.

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