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Impairment of cardiovascular autonomic pattern in obese adolescents with Type 2 diabetes mellitus.

Authors
  • Cerutti, F1
  • Rabbia, F
  • Rabbone, I
  • Bobbio, A
  • Ignaccolo, M G
  • Greco, G
  • Bertello, M C
  • Mulatero, P
  • Veglio, F
  • Pacini, G
  • 1 Department of Pediatrics, University of Turin, Piazza Polonia 96, 10126 Turin, Italy. [email protected] , (Italy)
Type
Published Article
Journal
Journal of Endocrinological Investigation
Publisher
Springer-Verlag
Publication Date
Sep 01, 2010
Volume
33
Issue
8
Pages
539–543
Identifiers
DOI: 10.3275/6863
PMID: 20160470
Source
Medline
License
Unknown

Abstract

serum lipids were significantly higher in obese and T2DM. Insulin sensitivity was significantly reduced in T2DM and obese vs controls; T2DM showed a more pronounced oral glucose insulin sensitivity (OGIS) reduction vs obese. Both obese and T2DM presented an higher IR. T2DM showed an impaired β-cell function, with insulin areas under the curve and disposition index significantly reduced in comparison to controls and obese who showed similar values. A progressive reduction of vagal indexes and an increase of sympathetic indexes were found in obese adolescents and were more pronounced in T2DM. These parameters were correlated with OGIS and β-cell function parameters in both obese and T2DM adolescents. T2DM showed a significant relative wall thickness increase suggesting a trend toward concentric remodeling. In conclusion, T2DM adolescents are characterized by a more marked IR reduced β-cell function in comparison to non-diabetic obese. These modifications may lead to an early impairment of the autonomic pattern.

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