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Impaired sarcoplasmic calcium release inhibits myocardial contraction in experimental sepsis.

Authors
Type
Published Article
Journal
Journal of Critical Care
0883-9441
Publisher
Elsevier
Publication Date
Volume
15
Issue
2
Pages
64–72
Identifiers
PMID: 10877367
Source
Medline

Abstract

These results indicate that myocardial dysfunction in sepsis is frequency dependent, and that the mechanism is most likely caused by inhibition of SR calcium release owing to blockade of the ryanodine channel.

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