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Impaired sarcoplasmic calcium release inhibits myocardial contraction in experimental sepsis.

Authors
  • Patel, D
  • Duke, K
  • Light, R B
  • Jacobs, H
  • Mink, S N
  • Bose, D
Type
Published Article
Journal
Journal of Critical Care
Publisher
Elsevier
Publication Date
Jun 01, 2000
Volume
15
Issue
2
Pages
64–72
Identifiers
PMID: 10877367
Source
Medline
License
Unknown

Abstract

These results indicate that myocardial dysfunction in sepsis is frequency dependent, and that the mechanism is most likely caused by inhibition of SR calcium release owing to blockade of the ryanodine channel.

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