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Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

Authors
  • Vardhana, Santosha A.1, 1, 2
  • Hwee, Madeline A.1, 1
  • Berisa, Mirela1
  • Wells, Daniel K.2
  • Yost, Kathryn E.3
  • King, Bryan1, 1
  • Smith, Melody1
  • Herrera, Pamela S.1, 4
  • Chang, Howard Y.3, 5
  • Satpathy, Ansuman T.2, 3
  • van den Brink, Marcel R. M.1
  • Cross, Justin R.1
  • Thompson, Craig B.1, 1
  • 1 Memorial Sloan Kettering Cancer Center, New York, NY, USA , New York (United States)
  • 2 Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA , San Francisco (United States)
  • 3 Stanford University School of Medicine, Stanford, CA, USA , Stanford (United States)
  • 4 Weill Cornell Medical College, New York, NY, USA , New York (United States)
  • 5 Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA , Stanford (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Jul 13, 2020
Volume
21
Issue
9
Pages
1022–1033
Identifiers
DOI: 10.1038/s41590-020-0725-2
Source
Springer Nature
License
Yellow

Abstract

Thompson and colleagues show that repetitive antigenic stimulation within the tumor environment triggers mitochondrial dysfunction by inhibiting oxidative phosphorylation, which leads to T cell exhaustion.

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