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Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure.

Authors
  • Lombardi, Angela1
  • Trimarco, Bruno2
  • Iaccarino, Guido3
  • Santulli, Gaetano4, 5
  • 1 Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.
  • 2 Department of Advanced Biomedical Sciences, "Federico II" University of Naples, Naples, Italy. , (Italy)
  • 3 Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Fisciano, Italy. , (Italy)
  • 4 Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA. [email protected]ail.com.
  • 5 Department of Advanced Biomedical Sciences, "Federico II" University of Naples, Naples, Italy. [email protected] , (Italy)
Type
Published Article
Journal
Cell communication and signaling : CCS
Publication Date
Nov 13, 2017
Volume
15
Issue
1
Pages
47–47
Identifiers
DOI: 10.1186/s12964-017-0203-0
PMID: 29132395
Source
Medline
Keywords
License
Unknown

Abstract

Our observations individuate a new fundamental mechanism responsible for the augmented incidence of diabetes following tacrolimus treatment. Indeed, this drug alters Ca2+ fluxes in mitochondria, thereby compromising metabolism-secretion coupling in beta-cells.

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