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Impaired microvascular vasodilator reserve in chronic cigarette smokers--a study of post-occlusive reactive hyperemia in the human finger.

Authors
Type
Published Article
Journal
Japanese circulation journal
Publication Date
Volume
58
Issue
1
Pages
29–33
Identifiers
PMID: 8139089
Source
Medline

Abstract

To assess the vasodilator reserve in microcirculation, post-occlusive reactive hyperemia was examined in 21 chronic cigarette smokers (mean age; 50 +/- 7 years) and 21 non-smokers (mean age; 51 +/- 6 years), who were all healthy males. Reactive hyperemia was induced by occluding the digital artery at the base of the middle finger, and the increase in skin blood flow (delta flow) was analyzed with a laser Doppler flowmeter. Occlusion time was increased in a step-wise manner from 30 sec up to 300 sec. Baseline skin blood flow was similar in both groups (smoker, 27 +/- 9 ml/min/100 g; non-smoker, 25 +/- 10 ml/min/100 g, NS). The delta flow in smokers was significantly less (23%-59%) than that in non-smokers. Furthermore, the reduced delta flow in smokers was inversely correlated with Brinkmann's smoking index (r = 0.567, p < 0.01). These results indicate that chronic cigarette smoking impairs the microvascular response to transient ischemia, and that this impairment correlates with the intensity of the smoking habit.

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