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Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia.

Authors
Type
Published Article
Journal
Gut
1468-3288
Publisher
BMJ
Publication Date
Volume
63
Issue
2
Pages
262–271
Identifiers
DOI: 10.1136/gutjnl-2012-303857
PMID: 23474421
Source
Medline
Keywords
License
Unknown

Abstract

These findings challenge the classical paradigm that patients with FD show no structural changes in the gastrointestinal tract. We suggest that impaired intestinal barrier function is a pathophysiological mechanism in FD. Thus, restoration of intestinal barrier integrity may be a potential therapeutic target for treating patients with FD.

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