Affordable Access

deepdyve-link
Publisher Website

Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia.

Authors
  • Vanheel, Hanne
  • Vicario, Maria
  • Vanuytsel, Tim
  • Van Oudenhove, Lukas
  • Martinez, Cristina
  • Keita, Åsa V
  • Pardon, Nicolas
  • Santos, Javier
  • Söderholm, Johan D
  • Tack, Jan
  • Farré, Ricard
Type
Published Article
Journal
Gut
Publisher
BMJ
Publication Date
Feb 01, 2014
Volume
63
Issue
2
Pages
262–271
Identifiers
DOI: 10.1136/gutjnl-2012-303857
PMID: 23474421
Source
Medline
Keywords
License
Unknown

Abstract

These findings challenge the classical paradigm that patients with FD show no structural changes in the gastrointestinal tract. We suggest that impaired intestinal barrier function is a pathophysiological mechanism in FD. Thus, restoration of intestinal barrier integrity may be a potential therapeutic target for treating patients with FD.

Report this publication

Statistics

Seen <100 times