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Impaired desensitization of a human polymorphic α2B-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells.

Authors
  • Nguyen, Kristy1
  • Kassimatis, Theodoros
  • Lymperopoulos, Anastasios
  • 1 Department of Pharmaceutical Sciences, College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA. [email protected]
Type
Published Article
Journal
Cell communication and signaling : CCS
Publication Date
Feb 07, 2011
Volume
9
Issue
1
Pages
5–5
Identifiers
DOI: 10.1186/1478-811X-9-5
PMID: 21299895
Source
Medline
License
Unknown

Abstract

This α2B-AR gene polymorphism (Glu301-303 deletion) might confer better protection against conditions characterized and aggravated by sympathetic/catecholaminergic overstimulation in vivo.

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