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Impaired activation-induced cell death promotes spontaneous arthritis in antigen (cartilage proteoglycan)-specific T cell receptor-transgenic mice.

Authors
  • Boldizsar, Ferenc
  • Kis-Toth, Katalin
  • Tarjanyi, Oktavia
  • Olasz, Katalin
  • Hegyi, Akos
  • Mikecz, Katalin
  • Glant, Tibor T
Type
Published Article
Journal
Arthritis & Rheumatism
Publisher
Wiley (John Wiley & Sons)
Publication Date
Oct 01, 2010
Volume
62
Issue
10
Pages
2984–2994
Identifiers
DOI: 10.1002/art.27614
PMID: 20564001
Source
Medline
License
Unknown

Abstract

The presence of CD4+ T cells expressing a TCR specific for an arthritogenic PG epitope is sufficient to trigger spontaneous autoimmune inflammation in the joints of BALB/c mice. IL-4 appears to be a negative regulator of this disease, through attenuation of activation-induced cell death.

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