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Impact of the tumor microenvironment on prognosis in follicular lymphoma is dependent on specific treatment protocols.

Authors
  • de Jong, Daphne
  • Koster, Ad
  • Hagenbeek, Anton
  • Raemaekers, John
  • Veldhuizen, Dennis
  • Heisterkamp, Sabien
  • de Boer, Jan Paul
  • van Glabbeke, Martine
Type
Published Article
Journal
Haematologica
Publisher
Ferrata Storti Foundation
Publication Date
Jan 01, 2009
Volume
94
Issue
1
Pages
70–77
Identifiers
DOI: 10.3324/haematol.13574
PMID: 19059937
Source
Medline
License
Unknown

Abstract

Our results suggest that characteristic properties of the microenvironment in follicular lymphoma determines the responses to essentially different chemotherapeutic approaches. These data may provide an explanation for the highly conflicting results on immunohistochemical markers and the prognostic role of the microenvironment in follicular lymphoma reported thus far and lay the basis for the development of predictive assays to tailor treatment in patients with follicular lymphoma.

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