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Impact of thalamocortical input on barrel cortex development.

Authors
  • Martini, Francisco J1
  • Moreno-Juan, Verónica2
  • Filipchuk, Anton2
  • Valdeolmillos, Miguel2
  • López-Bendito, Guillermina3
  • 1 Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), Sant Joan d'Alacant, Spain. Electronic address: [email protected] , (Spain)
  • 2 Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), Sant Joan d'Alacant, Spain. , (Spain)
  • 3 Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), Sant Joan d'Alacant, Spain. Electronic address: [email protected] , (Spain)
Type
Published Article
Journal
Neuroscience
Publication Date
Apr 13, 2017
Identifiers
DOI: 10.1016/j.neuroscience.2017.04.005
PMID: 28412498
Source
Medline
Keywords
License
Unknown

Abstract

The development of cortical maps requires the balanced interaction between genetically determined programs and input/activity-dependent signals generated spontaneously or triggered from the environment. The somatosensory pathway of mice provides an excellent scenario to study cortical map development because of its highly organized cytoarchitecture, known as the barrel field. This precise organization makes evident even small alterations in the cortical map layout. In this review, we will specially focus on the thalamic factors that control barrel field development. We will summarize the role of thalamic input integration and identity, neurotransmission and spontaneous activity in cortical map formation and early cross-modal plasticity.

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