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Impact of subarachnoid hemorrhage on local and global calcium signaling in cerebral artery myocytes.

Authors
  • Koide, Masayo
  • Nystoriak, Matthew A
  • Brayden, Joseph E
  • Wellman, George C
Type
Published Article
Journal
Acta neurochirurgica. Supplement
Publication Date
Jan 01, 2011
Volume
110
Issue
Pt 1
Pages
145–150
Identifiers
DOI: 10.1007/978-3-7091-0353-1_25
PMID: 21116930
Source
Medline
License
Unknown

Abstract

Our findings suggest decreased Ca2+ spark frequency leads to reduced BK channel activity in cerebral artery myocytes following SAH. This results in membrane potential depolarization, increased VDCC activity, elevated [Ca2+]i and decreased vessel diameter. We propose this mechanism of enhanced cerebral artery myocyte contractility may contribute to decreased cerebral blood flow and development of neurological deficits in SAH patients.

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