The impact of StuI digestion in situ on FISH to human chromosomes with satellite DNA probes.
- Published Article
Nature Publishing Group
- Publication Date
Apr 01, 2003
Human metaphase chromosomes were digested with StuI and subsequently hybridized in situ using chromosome 9 alphoid DNA and classical satellite III DNA as probes. The data obtained suggest that it is not possible to establish a general rule regarding the cytological effects induced by restriction enzymes in particular chromosome regions and that a number of factors, such as DNA sequences, DNA-protein interaction and enzyme structure, play a role in determining such effects.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/12692582