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The impact of a significant weight loss on inflammation assessed on DCE-MRI and static MRI in knee osteoarthritis: a prospective cohort study.

Authors
  • Daugaard, Cecilie Laubjerg1
  • Henriksen, Marius2
  • Riis, Robert Gc3
  • Bandak, Elisabeth4
  • Nybing, Janus Damm5
  • Hangaard, Stine6
  • Bliddal, Henning7
  • Boesen, Mikael8
  • 1 The Parker Institute, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark. Electronic address: [email protected] , (Denmark)
  • 2 The Parker Institute, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark; Dept. of Physical and Occupational Therapy, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark. Electronic address: [email protected] , (Denmark)
  • 3 Dept. of Radiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address: [email protected] , (Denmark)
  • 4 The Parker Institute, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark. Electronic address: [email protected] , (Denmark)
  • 5 Dept. of Radiology, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark. Electronic address: [email protected] , (Denmark)
  • 6 The Parker Institute, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark. Electronic address: [email protected] , (Denmark)
  • 7 The Parker Institute, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark. Electronic address: [email protected] , (Denmark)
  • 8 The Parker Institute, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark; Dept. of Radiology, Copenhagen University Hospital Bispebjerg-Frederiksberg, Copenhagen, Denmark. Electronic address: [email protected] , (Denmark)
Type
Published Article
Journal
Osteoarthritis and Cartilage
Publisher
Elsevier
Publication Date
Mar 09, 2020
Identifiers
DOI: 10.1016/j.joca.2020.02.837
PMID: 32165240
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To study the impact of weight loss on inflammation in individuals with overweight and knee osteoarthritis (OA) using both static- and dynamic contrast-enhanced (DCE)-MRI and assess the association of these changes to pain. Individuals with overweight (BMI > 27) and knee OA were examined before and after a >5% weight loss over 8 weeks (ClinicalTrials.gov NCT02905864). Using 3-Tesla MRI, inflammation was quantified from non-contrast enhanced static-MRI according to MOAKS and contrast enhanced static MRI according to BLOKS and 11-point whole-knee synovitis score. DCE-MRI was used to assess the inflammation in the infra patellar fat pad (IPFP). Pain was assessed using KOOS. Complete data were available in 117 participants with a mean age of 60 years, BMI of 35 kg/m2 and KOOS pain score of 64. Mean weight loss was 12 kg and KOOS pain was improved by 13 points at follow-up. Change in inflammation was not associated with weight loss in static MRI. None of the MRI variables correlated with the change in KOOS pain. Weight loss did not induce a significant change in inflammation in individuals with overweight and OA. The significant clinical beneficial effect of weight loss on knee pain in individuals with overweight and knee OA seems uncoupled to changes in imaging markers of synovitis. Copyright © 2020 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

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