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The impact of sex and age on T cell immunity and ischemic stroke outcomes.

Authors
  • Ahnstedt, Hilda1
  • McCullough, Louise D2
  • 1 Department of Neurology, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA. Electronic address: [email protected]
  • 2 Department of Neurology, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
Type
Published Article
Journal
Cellular Immunology
Publisher
Elsevier
Publication Date
Nov 01, 2019
Volume
345
Pages
103960–103960
Identifiers
DOI: 10.1016/j.cellimm.2019.103960
PMID: 31519365
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Sex differences are well-recognized in ischemic stroke, a disease mainly affecting the elderly. Stroke results in robust activation of central and peripheral immune responses which contributes to functional outcome. Aging is associated with increased low-grade chronic inflammation known as "inflammaging" that renders aged males and females more susceptible to poor outcomes after ischemic stroke. Despite the fact that sex differences are well-documented in immunity and inflammation, few studies have focused on sex differences in inflammatory responses after ischemic stroke and even fewer have been performed in the context of aging. The role of T cell responses in ischemic stroke have gained increasing attention over the past decade as data suggest a major role in the pathophysiology/recovery after ischemic injury. T cells offer an attractive therapeutic target due to their relatively delayed infiltration into the ischemic brain. This review will focus on T cell immune responses in ischemic stroke, highlighting studies examining the effects of aging and biological sex. Copyright © 2019 Elsevier Inc. All rights reserved.

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