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Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling.

Authors
  • Weisel, Friederike Christine
  • Kloepping, Christina
  • Pichl, Alexandra
  • Sydykov, Akylbek
  • Kojonazarov, Baktybek
  • Wilhelm, Jochen
  • Roth, Markus
  • Ridge, Karen Marie
  • Igarashi, Kazuei
  • Nishimura, Kazuhiro
  • Maison, Wolfgang
  • Wackendorff, Claudia
  • Klepetko, Walter
  • Jaksch, Peter
  • Ghofrani, Hossein Ardeschir
  • Grimminger, Friedrich
  • Seeger, Werner
  • Schermuly, Ralph Theo
  • Weissmann, Norbert
  • Kwapiszewska, Grazyna
Type
Published Article
Journal
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Publication Date
Apr 08, 2014
Volume
129
Issue
14
Pages
1510–1523
Identifiers
DOI: 10.1161/CIRCULATIONAHA.113.006402
PMID: 24470481
Source
Medline
Keywords
License
Unknown

Abstract

Our study indicates that genome-wide screening in mice from a PH model in which full reversal of PH occurs can be useful to identify potential key candidates for the reversal and development of PH. Targeting AMD-1 may represent a promising strategy for PH therapy.

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