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Impact of postoperative infective complications on long-term survival after liver resection for hepatocellular carcinoma.

Authors
  • Yang, T1
  • Liu, K1
  • Liu, C-F1
  • Zhong, Q2
  • Zhang, J1
  • Yu, J-J1
  • Liang, L1
  • Li, C1
  • Wang, M-D1
  • Li, Z-L1
  • Wu, H1
  • Xing, H1
  • Han, J1
  • Lau, W Y1, 3
  • Zeng, Y-Y4
  • Zhou, Y-H5
  • Gu, W-M6
  • Wang, H7
  • Chen, T-H8
  • Zhang, Y-M9
  • And 4 more
  • 1 Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. , (China)
  • 2 Department of Anaesthesiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. , (China)
  • 3 Faculty of Medicine, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China. , (China)
  • 4 Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital, Fujian Medical University, Fujian, China. , (China)
  • 5 Department of Hepatobiliary Surgery, Pu'er People's Hospital, Yunnan, China. , (China)
  • 6 First Department of General Surgery, Fourth Hospital of Harbin, Heilongjiang, China. , (China)
  • 7 Department of General Surgery, Liuyang People's Hospital, Hunan, China. , (China)
  • 8 Department of General Surgery, Ziyang First People's Hospital, Sichuan, China. , (China)
  • 9 Second Department of Hepatobiliary Surgery, Meizhou People's Hospital, Guangdong, China. , (China)
  • 10 Department of Hepatic Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China. , (China)
  • 11 Department of Surgery, Ohio State University, Wexner Medical Center, Columbus, Ohio, USA.
Type
Published Article
Journal
The British journal of surgery
Publication Date
Aug 01, 2019
Volume
106
Issue
9
Pages
1228–1236
Identifiers
DOI: 10.1002/bjs.11231
PMID: 31276196
Source
Medline
Language
English
License
Unknown

Abstract

Postoperative complications have a great impact on the postoperative course and oncological outcomes following major cancer surgery. Among them, infective complications play an important role. The aim of this study was to evaluate whether postoperative infective complications influence long-term survival after liver resection for hepatocellular carcinoma (HCC). Patients who underwent resection with curative intent for HCC between July 2003 and June 2016 were identified from a multicentre database (8 institutions) and analysed retrospectively. Independent risk factors for postoperative infective complications were identified. After excluding patients who died 90 days or less after surgery, overall survival (OS) and recurrence-free survival (RFS) were compared between patients with and without postoperative infective complications within 30 days after resection. Among 2442 patients identified, 332 (13·6 per cent) had postoperative infective complications. Age over 60 years, diabetes mellitus, obesity, cirrhosis, intraoperative blood transfusion, duration of surgery exceeding 180 min and major hepatectomy were identified as independent risk factors for postoperative infective complications. Univariable analysis revealed that median OS and RFS were poorer among patients with postoperative infective complications than among patients without (54·3 versus 86·8 months, and 22·6 versus 43·2 months, respectively; both P < 0·001). After adjustment for other prognostic factors, multivariable Cox regression analyses identified postoperative infective complications as independently associated with decreased OS (hazard ratio (HR) 1·20, 95 per cent c.i. 1·02 to 1·41; P = 0·027) and RFS (HR 1·19, 1·03 to 1·37; P = 0·021). Postoperative infective complications decreased long-term OS and RFS in patients treated with liver resection for HCC. © 2019 BJS Society Ltd. Published by John Wiley & Sons Ltd.

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