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Impact of personal and ambient-level exposures to nitrogen dioxide and particulate matter on cardiovascular function.

Authors
  • Williams, Ron
  • Brook, Robert
  • Bard, Robert
  • Conner, Teri
  • Shin, Hwashin
  • Burnett, Richard
Type
Published Article
Journal
International journal of environmental health research
Publication Date
Jan 01, 2012
Volume
22
Issue
1
Pages
71–91
Identifiers
DOI: 10.1080/09603123.2011.588437
PMID: 21711166
Source
Medline
License
Unknown

Abstract

This work explored the association between nitrogen dioxide (NO(2)) and PM(2.5) components with changes in cardiovascular function in an adult non-smoking cohort. The cohort consisted of 65 volunteers participating in the US EPA's Detroit Exposure and Aerosol Research Study (DEARS) and a University of Michigan cardiovascular sub-study. Systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), brachial artery diameter (BAD), brachial artery flow-mediated dilatation (FMD) and nitroglycerin-mediated arterial dilatation (NMD) were collected by in-home examinations. A maximum of 336 daily environmental and health effect observations were obtained. Daily potassium air concentrations were associated with significant decreases in DBP (-0.0447 mmHg/ng/m(3) ± 0.0132, p = 0.0016, lag day 0) among participants compliant with the personal monitoring protocol. Personal NO(2) exposures resulted in significant changes in BAD (e.g., 0.0041 mm/ppb ± 0.0019, p = 0.0353, lag day 1) and FMD (0.0612 ± 0.0235, p = 0.0103, lag day 0) among other findings.

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