Affordable Access

Publisher Website

Impact of overweight and obesity in the fetal cardiac function parameters in the second and third trimesters of pregnancy.

  • Peixoto, Alberto Borges1, 2
  • Bravo-Valenzuela, Nathalie Jeanne3
  • Martins, Wellington P4
  • Tonni, Gabriele5
  • Moron, Antonio Fernandes6
  • Mattar, Rosiane6
  • Ruano, Rodrigo7
  • Rolo, Liliam Cristine6
  • Araujo Júnior, Edward6
  • 1 Gynecology and Obstetrics Service, Mário Palmério University Hospital, University of Uberaba (UNIUBE), Uberaba-MG, Brazil. , (Brazil)
  • 2 Department of Obstetrics and Gynecology, Federal University of Triângulo Mineiro (UFTM), Uberaba-MG, Brazil. , (Brazil)
  • 3 Department of Pediatrics, Pediatric Cardiology, School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro-RJ, Brazil. , (Brazil)
  • 4 SEMEAR Fertilidade, Reproductive Medicine, Ribeirão Preto-SP, Brazil. , (Brazil)
  • 5 Department of Obstetrics and Neonatology, Prenatal Diagnostic Centre, Istituto di Cura e Ricovero a Carattere Scientifico (IRCCS), AUSL Reggio Emilia, Italy. , (Italy)
  • 6 Department of Obstetrics, Paulista School of Medicine - Federal University of São Paulo (EPM-UNIFESP), São Paulo-SP, Brazil. , (Brazil)
  • 7 Department of Maternal and Fetal Medicine, Fetal Surgery Service, Obstetrics and GynecologyUniversity of Miami, Miller School of Medicine, Miami, Fl, USA.
Published Article
Cardiology in the Young
Cambridge University Press
Publication Date
Feb 01, 2024
DOI: 10.1017/S1047951123001609
PMID: 37408451


To assess the impact of overweight and obesity in the second and third trimesters of pregnancy on fetal cardiac function parameters. We performed a prospective cohort study of 374 singleton pregnant women between 20w0d and 36w6d divided into three groups: 154 controls (body mass index - BMI < 25 kg/m2), 140 overweight (BMI 25-30 kg/m2) and 80 obese (BMI ≥ 30 kg/m2). Fetal left ventricular (LV) modified myocardial performance index (Mod-MPI) was calculated according to the following formula: (isovolumetric contraction time + isovolumetric relaxation time)/ejection time. Spectral tissue Doppler was used to determine LV and right ventricular (RV) myocardial performance index (MPI'), peak myocardial velocity during systole (S'), early diastole (E'), and late diastole (A'). We found significant differences between the groups in maternal age (p < 0.001), maternal weight (p < 0.001), BMI (p < 0.001), number of pregnancies (p < 0.001), parity (p < 0.001), gestational age (p = 0.013), and estimated fetal weight (p = 0.003). Overweight pregnant women had higher LV Mod-MPI (0.046 versus 0.044 seconds, p = 0.009) and LV MPI' (0.50 versus 0.47 seconds, p < 0.001) than the control group. Obese pregnant women had higher RV E' than control (6.82 versus 6.33 cm/sec, p = 0.008) and overweight (6.82 versus 6.46 cm/sec, p = 0.047) groups. There were no differences in 5-min APGAR score < 7, neonatal intensive care unit admission, hypoglycemia and hyperglobulinemia between the groups. We observed fetal myocardial dysfunction in overweight and obese pregnant women with higher LV Mod-MPI, LV MPI' and RV E' compared to fetuses from normal weight pregnant women.

Report this publication


Seen <100 times