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Impact of non-surgical periodontal therapy on serum Resistin and periodontal pathogen in periodontitis patients with obesity

  • Md Tahir, Khairunnisa1
  • Ab Malek, Ainul Haliza1
  • Vaithilingam, Rathna Devi1
  • Saub, Roslan1
  • Safii, Syarida Hasnur1
  • Rahman, Mohammad Tariqur1
  • Abdul Razak, Fathilah1, 2
  • Alabsi, Aied M3
  • Baharuddin, Nor Adinar1
  • 1 University of Malaya, Lembah Pantai, Kuala Lumpur, 50603, Malaysia , Kuala Lumpur (Malaysia)
  • 2 Universitas Airlangga, Surabaya, Indonesia , Surabaya (Indonesia)
  • 3 Faculty of Dentistry, MAHSA University, Jalan SP2, Bandar Saujana Putra, Jenjarom Kuala Langat, Selangor, 42610, Malaysia , Jenjarom Kuala Langat (Malaysia)
Published Article
BMC Oral Health
Springer (Biomed Central Ltd.)
Publication Date
Feb 14, 2020
DOI: 10.1186/s12903-020-1039-3
Springer Nature


BackgroundNon-surgical periodontal therapy (NSPT) known as gold standard treatment in managing periodontitis. The aim of this study was to investigate the response of NSPT in periodontitis subjects who were obese. Clinical parameters of periodontitis, changes in serum resistin and periodontal pathogens in subgingival plaque were compared before and after NSPT in periodontitis subjects who were obese and with normal weight.MethodsA total of 48 periodontitis subjects (obese, n = 18; normal weight, n = 30) were recruited (hereafter will be referred as participants) to participate into a prospective, before and after clinical trial. Obesity status is defined by body mass index (BMI) criteria (obese: ≥30 kg/ m2; normal weight < 25 kg/m2). Visible Plaque Index (VPI), Gingival Bleeding Index (GBI), Probing Pocket Depth (PPD) and Clinical Attachment Loss (CAL) were recorded; and serum and plaque were collected at baseline and following 12 weeks post-NSPT. Serum resistin level was analyzed using enzyme-linked immune-sorbant assay (ELISA), while detection of periodontal pathogens in dental plaque were carried out using real time PCR (qPCR).ResultsFollowing NSPT, means VPI and GBI showed significant improvement between obese and normal weight groups (p < 0.05), but no difference in means PPD and CAL was observed between groups. Obesity remained as a predictor for VPI and GBI after adjusting for smoking habit. No significant difference was observed in serum resistin level and mean counts for P. gingivalis, T. forsythia, and P. intermedia between obese and normal weight groups following NSPT.ConclusionsRegardless of obesity status, NSPT has a significant impact on VPI and GBI in periodontitis subjects. However, the impact of NSPT towards serum resistin and periodontal pathogens was non-significant in those with periodontitis.Trial registrationThis study followed the Consolidation Standards of Reporting Trials Statement and retrospectively registered on 26/11/2015 at (No. NCT02618486).

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