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Impact of a Music Intervention on Quality of Life in Breast Cancer Patients Undergoing Chemotherapy: A Randomized Clinical Trial

  • Lima, Talita Uchoa1
  • Moura, Ed Carlos Rey1
  • de Oliveira, Caio Márcio Barros1
  • Leal, Rachel Jorge Dino Cossetti2
  • Nogueira Neto, João1
  • Pereira, Emanuel Cabral1
  • Nascimento, Raniere Victor Braga1
  • de Oliveira, Eduardo José Silva Gomes1
  • Leal, Plínio da Cunha1
  • 1 Federal University of Maranhão, Sao Luis, Maranhão, Brazil
  • 2 UDI and Aldenora Bello Hospitals, Sao Luis, Maranhão, Brazil
Published Article
Integrative Cancer Therapies
SAGE Publications
Publication Date
Jul 03, 2020
DOI: 10.1177/1534735420938430
PMID: 32618212
PMCID: PMC7491226
PubMed Central


Background: Music can influence human behavior and may be used as a complementary therapy in health care. Objectives: To assess the effect of music interventions on symptoms, adverse events, and quality of life (QoL) of breast cancer patients undergoing chemotherapy (CT). Design: Nonblinded, randomized clinical trial. Women with breast cancer undergoing adjuvant CT were randomized into 2 groups—Group Music (GM) or Group Control (GC)—and followed during the first 3 cycles of treatment. Measurements: Sociodemographic data, WHOQOL-BREF, BDI-II, BAI, and Chemotherapy Toxicity Scale were assessed. Patients were evaluated after each session of the first 3 CT cycles. GM underwent a 30-minute musical intervention before CT. There was no intervention in the GC. Continuous data were analyzed by Student’s t test, and χ2 test was used to compare qualitative variables. Results: Higher QoL scores on functional scales were observed for the GM in comparison to the GC after the first and third sessions of CT. Depression ( P < .001) and anxiety scores ( P < .001) and vomiting ( P < .01) incidence were lower for the GM in the third session of CT. All the participants in the GM reported positive changes in life in the Subjective Impression of the Subject questionnaire, as well as improvement in fatigue and reduced stress levels. Conclusions: Improvements in QoL, anxiety, depression, and incidence of vomiting were associated with the music intervention, suggesting a positive effect of the music intervention on adverse events of cancer CT.

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