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The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADHD Drugs Use Chronic Effects (ADDUCE) Project

  • Carucci, Sara
  • Zuddas, Alessandro
  • Lampis, Angelico
  • Man, Kenneth KC
  • Balia, Carla
  • Buitelaar, Jan
  • Danckaerts, Marina
  • Dittmann, Ralf W
  • Donno, Federica
  • Falissard, Bruno
  • Gagliano, Antonella
  • Garas, Peter
  • Häge, Alexander
  • Hollis, Chris
  • Inglis, Sarah K
  • Konrad, Kerstin
  • Kovshoff, Hanna
  • Liddle, Elizabeth
  • McCarthy, Suzanne
  • Neubert, Antje
  • And 6 more
Publication Date
Feb 17, 2024
UCL Discovery
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Objective: The short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age.// Method: Participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age.// Results: The medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable.// Conclusion: Our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.

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