Affordable Access

Impact of Human Leukocyte Antigen Allele-Killer Cell Immunoglobulin-like Receptor Partners on Sexually Transmitted Human Immunodeficiency Virus Type 1 Infection.

Authors
  • Serrano-Rísquez, Carmen
  • Omar, Mohamed
  • Rallón, Norma
  • Benito, José
  • Gómez-Vidal, Amparo
  • Márquez, Francisco
  • Alján, Martina
  • Rivero-Juárez, Antonio
  • Pérez-Valero, Ignacio
  • Rivero, Antonio
  • Sinangil, Faruk
  • Saulle, Irma
  • Biasin, Mara
  • Clerici, Mario
  • Forthal, Donald
  • Saéz, Maria
  • Caruz, Antonio
Publication Date
Nov 15, 2024
Source
eScholarship - University of California
Keywords
License
Unknown
External links

Abstract

Human leukocyte antigen (HLA) class I/killer cell immunoglobulin-like receptor (KIR) genotypes influence human immunodeficiency virus type 1 (HIV-1) disease progression and viral load, but their role in primary infection is uncertain. Inconsistent results from previous studies suggest that the inoculum size and transmission route-parenteral versus sexual-may influence this association. We conducted a genome-wide association study in a population of people with HIV-1 and HIV-1-exposed seronegative individuals exposed to the virus through the sexual route. Our data do not support any role of the HLA/KIR system in susceptibility to sexually transmitted HIV-1 infection. The genetics basis of HIV-1 viral load and disease progression are distinct from the genetics of HIV resistance, a paradox worth exploring.

Report this publication

Statistics

Seen <100 times