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The impact of dietary fatty acids on human adipose tissue.

Authors
  • Petrus, Paul1
  • Arner, Peter1
  • 1 Department of Medicine (H7), Karolinska Institutet, Stockholm141 86, Sweden. , (Sweden)
Type
Published Article
Journal
Proceedings of The Nutrition Society
Publisher
Cambridge University Press
Publication Date
Feb 01, 2020
Volume
79
Issue
1
Pages
42–46
Identifiers
DOI: 10.1017/S0029665119000624
PMID: 31122299
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Nutrition is a major variable factor in human environments. The composition of nutrients has changed markedly in recent decades which may contribute to the increased prevalence of metabolic diseases, such as obesity and type 2 diabetes. Fat is an important component of the diet which comes in various forms with fatty acids (FA) of different carbon chain lengths and saturation degrees. In addition to being an energy supply, FA function as potent signalling molecules and influence transcriptional activity. Among other tissues, dietary FA target white adipose tissue function, which is central in maintaining metabolic health. This review focuses on the possible role of dietary FA composition and its effect on human white adipose tissue expandability and transcriptional response. Altogether, the existing literature suggests that unsaturated fat has more benign effects on adipose tissue distribution when compared to long-chain saturated fat. However, the mechanisms of action remain poorly characterised.

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