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The impact of demographic, clinical, genetic, and imaging variables on tau PET status.

  • Ossenkoppele, Rik
  • Leuzy, Antoine
  • Cho, Hanna
  • Sudre, Carole H
  • Strandberg, Olof
  • Smith, Ruben
  • Palmqvist, Sebastian
  • Mattsson-Carlgren, Niklas
  • Olsson, Tomas
  • Jögi, Jonas
  • Stormrud, Erik
  • Ryu, Young Hoon
  • Choi, Jae Yong
  • neuroimaging initiative, alzheimer’s dis...
  • group, prevent-ad research
  • Boxer, Adam L
  • Gorno-Tempini, Maria L
  • Miller, Bruce L
  • Soleimani-Meigooni, David
  • Iaccarino, Leonardo
  • And 9 more
Publication Date
Jul 01, 2021
eScholarship - University of California
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PurposeA substantial proportion of amyloid-β (Aβ)+ patients with clinically diagnosed Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI) are tau PET-negative, while some clinically diagnosed non-AD neurodegenerative disorder (non-AD) patients or cognitively unimpaired (CU) subjects are tau PET-positive. We investigated which demographic, clinical, genetic, and imaging variables contributed to tau PET status.MethodsWe included 2338 participants (430 Aβ+ AD dementia, 381 Aβ+ MCI, 370 non-AD, and 1157 CU) who underwent [18F]flortaucipir (n = 1944) or [18F]RO948 (n = 719) PET. Tau PET positivity was determined in the entorhinal cortex, temporal meta-ROI, and Braak V-VI regions using previously established cutoffs. We performed bivariate binary logistic regression models with tau PET status (positive/negative) as dependent variable and age, sex, APOEε4, Aβ status (only in CU and non-AD analyses), MMSE, global white matter hyperintensities (WMH), and AD-signature cortical thickness as predictors. Additionally, we performed multivariable binary logistic regression models to account for all other predictors in the same model.ResultsTau PET positivity in the temporal meta-ROI was 88.6% for AD dementia, 46.5% for MCI, 9.5% for non-AD, and 6.1% for CU. Among Aβ+ participants with AD dementia and MCI, lower age, MMSE score, and AD-signature cortical thickness showed the strongest associations with tau PET positivity. In non-AD and CU participants, presence of Aβ was the strongest predictor of a positive tau PET scan.ConclusionWe identified several demographic, clinical, and neurobiological factors that are important to explain the variance in tau PET retention observed across the AD pathological continuum, non-AD neurodegenerative disorders, and cognitively unimpaired persons.

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