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Impact of curcumin supplementation on expression of inflammatory transcription factors in hemodialysis patients: A pilot randomized, double-blind, controlled study.

Authors
  • Alvarenga, Livia1
  • Salarolli, Roberta2
  • Cardozo, Ludmila F M F3
  • Santos, Rhayssa S4
  • de Brito, Jessyca S5
  • Kemp, Julie Ann3
  • Reis, Drielly5
  • de Paiva, Bruna Regis3
  • Stenvinkel, Peter6
  • Lindholm, Bengt6
  • Fouque, Denis7
  • Mafra, Denise8
  • 1 Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Niterói, Brazil. Electronic address: [email protected] , (Brazil)
  • 2 Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Niterói, Brazil. , (Brazil)
  • 3 Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, Brazil. , (Brazil)
  • 4 College of Nutrition, Fluminense Federal University (UFF), Niterói, Brazil. , (Brazil)
  • 5 Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Niterói, Brazil. , (Brazil)
  • 6 Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Technology and Intervention, Karolinska Institutet, Stockholm, Sweden. , (Sweden)
  • 7 Department of Nephrology, Centre Hopitalier Lyon Sud, INSERM 1060, CENS, Université de Lyon, France. , (France)
  • 8 Graduate Program in Medical Sciences, Fluminense Federal University (UFF), Niterói, Brazil; Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Niterói, Brazil; Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, Brazil; College of Nutrition, Fluminense Federal University (UFF), Niterói, Brazil. , (Brazil)
Type
Published Article
Journal
Clinical nutrition (Edinburgh, Scotland)
Publication Date
Dec 01, 2020
Volume
39
Issue
12
Pages
3594–3600
Identifiers
DOI: 10.1016/j.clnu.2020.03.007
PMID: 32204978
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Chronic kidney disease (CKD) patients have numerous complications associated with inflammation, which is a potential driver for cardiovascular disease. Curcumin, a compound of the curcuminoid class produced by the Curcuma longa, has been reported to activate nuclear factor erythroid factor 2-related (Nrf2) and inhibit nuclear factor kappa-B (NF-kB). Our aim was to evaluate the effects of curcumin juice on the expression of inflammatory transcription factors in hemodialysis (HD) patients. This double-blind randomized pilot study included 31 HD patients divided into two groups: curcumin group (receiving 100 mL of orange juice with 12 g of carrot and 2.5 g of turmeric after each dialysis session/week for 3 months) and control group (receiving the same juice without curcumin); 14 patients in each arm completed the study. The mRNA expression of Nrf2, NF-kB, NLRP3 inflammasome and IL-1β in peripheral blood mononuclear cells (PBMC; using real-time quantitative polymerase chain reaction, qPCR) and routine biochemistries, food intake and anthropometrics were analyzed. After three months of supplementation, the curcumin group showed a significant decrease in NF-kB mRNA expression (AU) [from 1.08 (0.77-1.38) to 0.52 (0.32-0.95),p = 0.02] and in plasma high sensitivity C-reactive protein (hsCRP) levels [from 3.8 (2.5-6.8) to 2.0 (1.1-3.8) mg/L, p = 0.04]. There was no change in the other evaluated markers. Three months treatment with curcumin in CKD patients undergoing HD resulted in decreased markers of inflammation, NF-kB mRNA expression and hsCRP, suggesting that oral supplementation of curcumin may have an anti-inflammatory effect in this patient group. Approved by the Ethics Committee of the Faculty of Medicine/UFF, number: 2.346.933. This study was registered within ClinicalTrials.gov under the number NCT03475017. Copyright © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

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