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Impact of Chromatin on HIV Replication.

Authors
  • Agosto, Luis M
  • Gagne, Matthew
  • Henderson, Andrew J
Type
Published Article
Journal
Genes
Publication Date
Jan 01, 2015
Volume
6
Issue
4
Pages
957–976
Identifiers
DOI: 10.3390/genes6040957
PMID: 26437430
Source
Medline
Keywords
License
Unknown

Abstract

Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated factors to reduce the HIV proviral load are discussed.

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