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The Impact of Childhood Attention-Deficit/Hyperactivity Disorder (ADHD) on Children’s Health-Related Quality of Life: A Systematic Review and Meta-Analysis

Authors
  • Wanni Arachchige Dona, Sithara1
  • Badloe, Nalini1
  • Sciberras, Emma1, 2, 3
  • Gold, Lisa1
  • Coghill, David2, 3
  • Le, Ha N. D.1
  • 1 Deakin University, Burwood, VIC, Australia
  • 2 Royal Children’s Hospital, Parkville, VIC, Australia
  • 3 The University of Melbourne, Parkville, VIC, Australia
Type
Published Article
Journal
Journal of Attention Disorders
Publisher
SAGE Publications
Publication Date
Feb 17, 2023
Volume
27
Issue
6
Pages
598–611
Identifiers
DOI: 10.1177/10870547231155438
PMID: 36800919
PMCID: PMC10068409
Source
PubMed Central
Keywords
Disciplines
  • Practical Meta-Analyses
License
Unknown

Abstract

Objective: To investigate the association between children’s health-related quality of life (HRQoL) and childhood attention-deficit/hyperactivity disorder (ADHD). Method: Databases were systematically searched for peer-reviewed literature published between 2010 and 2022. Two reviewers independently screened and assessed the quality of included studies. Meta-analysis was conducted for studies that used the Pediatric Quality of Life Inventory (PedsQL). Results: Twenty-three studies were included, with most rated as “good” quality. Meta-analysis found “very large” effect in both parent- (Hedges’ g −1.67, 95% CI [−2.57, −0.78]) and child-reported (Hedges’ g −1.28, 95% CI [−2.01, −0.56]) HRQoL for children with ADHD compared to children without ADHD. No difference between parent- and child-reported HRQoL in children with and without ADHD was found. However, parent-reported HRQoL was lower than child-reported HRQoL among children with ADHD. Conclusion: ADHD was associated with substantially poorer children’s HRQoL. Among children with ADHD, parents rated their children’s HRQoL lower than the children themselves.

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