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Impact of adaptive gastric electrical stimulation on weight, food intake, and food intake rate in dogs.

Authors
  • Debelle, Adrien1
  • Hesta, Myriam2
  • de Rooster, Hilde3
  • Bianchini, Erika3
  • Vanhoestenberghe, Anne4
  • Stock, Emmelie2
  • Vanderperren, Katrien2
  • Polis, Ingeborgh3
  • Smets, Hugo1
  • Cury, Joaquin1
  • Acuña, Vicente1
  • Delchambre, Alain1
  • Innocenti, Bernardo1
  • Devière, Jacques5
  • Nonclercq, Antoine1
  • 1 Bio, Electro and Mechanical Systems Department, Ecole polytechnique de Bruxelles, Université libre de Bruxelles, Brussels, Belgium. , (Belgium)
  • 2 Department of Veterinary Medical Imaging and Small Animal Orthopedics, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium. , (Belgium)
  • 3 Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium. , (Belgium)
  • 4 Aspire Centre for Rehabilitation Engineering and Assistive Technology, Department of Materials and Tissue, University College London, Stanmore, UK.
  • 5 Department of Gastroenterology, Hepatopancreatology, and Digestive Oncology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium. , (Belgium)
Type
Published Article
Journal
Artificial organs
Publication Date
Jun 01, 2022
Volume
46
Issue
6
Pages
1055–1067
Identifiers
DOI: 10.1111/aor.14156
PMID: 34932224
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Gastric electrical stimulation (GES) has been studied for decades as a promising treatment for obesity. Stimulation pulses with fixed amplitude and pulse width are usually applied, but these have limitations with regard to overcoming habituation to GES and inter-subject variation. This study aims to analyze the efficacy of an adaptive GES protocol for reducing food intake and maintaining lean weight in dogs. Six beagle dogs were implanted with a remotely programmable gastric stimulator. An adaptive protocol was designed to increase the stimulation energy proportionally to the excess of food consumption, with respect to the dogs' maintenance energy requirements. After surgery and habituation to experimental conditions, the dogs went through both a control and a stimulation period of 4 weeks each, in a randomized order. The stimulation parameters were adapted daily. Body weight, food intake, food intake rate, and postprandial cutaneous electrogastrograms (EGG) were recorded to assess the effect of adaptive GES. Adaptive GES decreased food intake and food intake rate (p < 0.05) resulting in weight maintenance. In the absence of GES, the dogs gained weight (p < 0.05). Postprandial EGG dominant frequency was accelerated by GES (p < 0.05). The strategy of adapting the stimulation energy was effective in causing significant mid-term changes. Adaptive GES is effective for reducing food intake and maintaining lean weight. The proposed adaptive strategy may offer benefits to counter habituation and adapt to inter-subject variation in clinical use of GES for obesity. © 2021 International Center for Artificial Organs and Transplantation and Wiley Periodicals LLC.

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