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Immunotherapy for glioma: Current management and future application.

Authors
  • Xu, Shengchao1
  • Tang, Lu2
  • Li, Xizhe2
  • Fan, Fan3
  • Liu, Zhixiong4
  • 1 Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, People's Republic of China. , (China)
  • 2 Department of Thoracic Surgery, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, People's Republic of China. , (China)
  • 3 Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, People's Republic of China. Electronic address: [email protected] , (China)
  • 4 Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, People's Republic of China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Cancer letters
Publication Date
Apr 28, 2020
Volume
476
Pages
1–12
Identifiers
DOI: 10.1016/j.canlet.2020.02.002
PMID: 32044356
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Gliomas are intrinsic brain tumors that originate from neuroglial progenitor cells. Conventional therapies, including surgery, chemotherapy, and radiotherapy, have achieved limited improvements in the prognosis of glioma patients. Immunotherapy, a revolution in cancer treatment, has become a promising strategy with the ability to penetrate the blood-brain barrier since the pioneering discovery of lymphatics in the central nervous system. Here we detail the current management of gliomas and previous studies assessing different immunotherapies in gliomas, despite the fact that the associated clinical trials have not been completed yet. Moreover, several drugs that have undergone clinical trials are listed as novel strategies for future application; however, these clinical trials have indicated limited efficacy in glioma. Therefore, additional studies are warranted to evaluate novel therapeutic approaches in glioma treatment. Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

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