Immunosuppression, nonspecific B-cell activation, and mitogenic activity associated with a high molecular weight component from Listeria monocytogenes.
- Published Article
Canadian journal of microbiology
- Publication Date
Dec 01, 1982
A high molecular component of a saline extract derived from Listeria monocytogenes contained amino acids, carbohydrates, and phosphorus. The same fraction was capable of promoting both the in vitro mitogenic and adjuvant activities and the in vivo immunosuppressive activity displayed by the crude extract. The material was mitogenic to B but not to T lymphocytes in vitro. Responses to sheep and horse erythrocytes as well as to lipopolysaccharide were suppressed. Immunosuppression was dose dependent and was present at 1, 2, or 3 days but absent 7 days after injection. Both primary and secondary responses to sheep erythrocytes were impaired.
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This record was last updated on 07/01/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/6820330