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Immunosuppression, nonspecific B-cell activation, and mitogenic activity associated with a high molecular weight component from Listeria monocytogenes.

Authors
  • Otokunefor, T V
  • Galsworthy, S B
Type
Published Article
Journal
Canadian journal of microbiology
Publication Date
Dec 01, 1982
Volume
28
Issue
12
Pages
1373–1381
Identifiers
PMID: 6820330
Source
Medline
License
Unknown

Abstract

A high molecular component of a saline extract derived from Listeria monocytogenes contained amino acids, carbohydrates, and phosphorus. The same fraction was capable of promoting both the in vitro mitogenic and adjuvant activities and the in vivo immunosuppressive activity displayed by the crude extract. The material was mitogenic to B but not to T lymphocytes in vitro. Responses to sheep and horse erythrocytes as well as to lipopolysaccharide were suppressed. Immunosuppression was dose dependent and was present at 1, 2, or 3 days but absent 7 days after injection. Both primary and secondary responses to sheep erythrocytes were impaired.

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