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Immunosuppression of collagen-induced arthritis in mice with an anti-IL-2 receptor antibody.

Authors
  • Banerjee, S
  • Wei, B Y
  • Hillman, K
  • Luthra, H S
  • David, C S
Type
Published Article
Journal
Journal of immunology (Baltimore, Md. : 1950)
Publication Date
Aug 15, 1988
Volume
141
Issue
4
Pages
1150–1154
Identifiers
PMID: 3135321
Source
Medline
License
Unknown

Abstract

The use of an anti-IL-2R antibody, 7D4, was investigated in vivo in the suppression of collagen-induced arthritis in mice. 7D4 was shown to reduce the incidence of arthritis in a group of mice immunized with type II collagen as compared with a group similarly immunized with collagen and treated with a control isotype matched anti-Forsmann antibody. 7D4 was also shown to reduce the severity of arthritis in the treated mice as compared to the mice in the group treated with the control antibody. Anti-IL-2R antibodies may be useful in the treatment of autoimmune diseases by selectively suppressing activated T cells.

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