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Immunosuppression with 4SC-101, a novel inhibitor of dihydroorotate dehydrogenase, in a rat model of renal transplantation.

Authors
  • Rusai, Krisztina
  • Schmaderer, Christoph
  • Baumann, Marcus
  • Chmielewski, Stefan
  • Prókai, Agnes
  • Kis, Eva
  • Szabó, Attila J
  • Leban, Johann
  • Doblhofer, Robert
  • Ammendola, Aldo
  • Lutz, Jens
  • Heemann, Uwe
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jun 14, 2012
Volume
93
Issue
11
Pages
1101–1107
Identifiers
DOI: 10.1097/TP.0b013e31824fd861
PMID: 22609757
Source
Medline
License
Unknown

Abstract

4SC-101 prolongs survival after Tx, paralleled by amelioration of histologic signs of acute rejection. Furthermore, it showed no worsening effects on kidney function in a remnant kidney model and even slowed the progression of proteinuria and kidney fibrosis. Therefore, 4SC-101 might be a promising pharmaceutical agent in Tx medicine for further investigations.

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