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Immunopathology and dexamethasone therapy in a new model for malaria-associated acute respiratory distress syndrome.

Authors
  • Van den Steen, Philippe E1
  • Geurts, Nathalie
  • Deroost, Katrien
  • Van Aelst, Ilse
  • Verhenne, Sebastien
  • Heremans, Hubertine
  • Van Damme, Jo
  • Opdenakker, Ghislain
  • 1 Laboratory of Immunobiology, Rega Institute for Medical Research, Catholic University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium. [email protected] , (Belgium)
Type
Published Article
Journal
American Journal of Respiratory and Critical Care Medicine
Publisher
American Thoracic Society
Publication Date
May 01, 2010
Volume
181
Issue
9
Pages
957–968
Identifiers
DOI: 10.1164/rccm.200905-0786OC
PMID: 20093644
Source
Medline
License
Unknown

Abstract

We developed a novel model of MA-ARDS with many similarities to human MA-ARDS and without cerebral complications. This contrasts with the more classical model with P. berghei ANKA, characterized by fulminant cerebral malaria. Hence, infection with P. berghei NK65 generates a broader time window to study the pathogenesis and to evaluate candidate treatments. The finding that high doses of dexamethasone cured MA-ARDS suggests that it might be more effective against MA-ARDS than it was in the clinical trials for cerebral malaria.

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