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Immunonutrition in Acute Respiratory Distress Syndrome

Authors
  • Aqeel, Masooma1
  • Ahmad, Shahryar1
  • Patel, Jayshil J.2
  • Rice, Todd W.3
  • 1 Froedtert and Medical College of Wisconsin, 9200 West Wisconsin Avenue, Suite E5200, Milwaukee, WI, 53226, USA , Milwaukee (United States)
  • 2 Froedtert and Medical College of Wisconsin, Milwaukee, WI, USA , Milwaukee (United States)
  • 3 Vanderbilt University Medical Center, Nashville, TN, USA , Nashville (United States)
Type
Published Article
Journal
Current Pulmonology Reports
Publisher
Springer US
Publication Date
Apr 11, 2017
Volume
6
Issue
2
Pages
113–123
Identifiers
DOI: 10.1007/s13665-017-0171-2
Source
Springer Nature
Keywords
License
Yellow

Abstract

Purpose of ReviewDietary supplementation with nutrients such as glutamine and omega-3 fatty acids to modulate/boost host immunity in critical illness is a new concept. We review current evidence (animal and human studies) on the role of immunonutrition in acute respiratory distress syndrome (ARDS).Recent FindingsDietary supplementation during stress states (ARDS) with omega-3 fatty acids has been shown to attenuate inflammation and improve lung microvascular permeability in animals. In humans, omega-3 fatty acid supplementation has shown mixed results. While studies show improvement in oxygenation and lung mechanics, a recent study demonstrated increased mortality with omega-3 fatty acids. Similarly, animal studies suggest that lower glutamine levels are associated with worse outcomes in surgical and septic patients. But, a recent study in humans has shown an increased trend towards all-cause mortality.SummaryCurrent evidence is conflicting and does not support use of immune-modulating therapies (glutamine or omega-3 fatty acids) in ARDS.

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