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Immunomodulatory Function of Myeloid-Derived Suppressor Cells during B Cell-Mediated Immune Responses.

Authors
  • Özkan, Bilgenaz1
  • Lim, Heejin2
  • Park, Sung-Gyoo3
  • 1 School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea. [email protected] , (North Korea)
  • 2 School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea. [email protected] , (North Korea)
  • 3 School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea. [email protected] , (North Korea)
Type
Published Article
Journal
International Journal of Molecular Sciences
Publisher
MDPI AG
Publication Date
May 15, 2018
Volume
19
Issue
5
Identifiers
DOI: 10.3390/ijms19051468
PMID: 29762501
Source
Medline
Keywords
License
Unknown

Abstract

Myeloid-derived suppressor cells (MDSCs) play roles in immune regulation during neoplastic and non-neoplastic inflammatory responses. This immune regulatory function is directed mainly toward T cells. However, MDSCs also regulate other cell populations, including B cells, during inflammatory responses. Indeed, B cells are essential for antibody-mediated immune responses. MDSCs regulate B cell immune responses directly via expression of effector molecules and indirectly by controlling other immune regulatory cells. B cell-mediated immune responses are a major component of the overall immune response; thus, MDSCs play a prominent role in their regulation. Here, we review the current knowledge about MDSC-mediated regulation of B cell responses.

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