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Immunology of COVID-19: Current State of the Science

Authors
  • Vabret, Nicolas1
  • Britton, Graham J.1
  • Gruber, Conor1
  • Hegde, Samarth1
  • Kim, Joel1
  • Kuksin, Maria1
  • Levantovsky, Rachel1
  • Malle, Louise1
  • Moreira, Alvaro1
  • Park, Matthew D.1
  • Pia, Luisanna1
  • Risson, Emma1
  • Saffern, Miriam1
  • Salomé, Bérengère1
  • Esai Selvan, Myvizhi1
  • Spindler, Matthew P.1
  • Tan, Jessica1
  • van der Heide, Verena1
  • Gregory, Jill K.1
  • Alexandropoulos, Konstantina1
  • And 68 more
  • 1 Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA
Type
Published Article
Journal
Immunity
Publication Date
May 06, 2020
Volume
52
Issue
6
Pages
910–941
Identifiers
DOI: 10.1016/j.immuni.2020.05.002
PMID: 32505227
PMCID: PMC7200337
Source
PubMed Central
License
Unknown

Abstract

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.

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