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Immunological effects of recombinant feline interferon-omega (KT-80) administration in the dog.

Authors
  • Kuwabara, Masato
  • Nariai, Youko
  • Horiuchi, Yutaka
  • Nakajima, Yuko
  • Yamaguchi, Yu
  • Horioka, Eriko
  • Kawanabe, Mikiko
  • Kubo, Takuya
  • Yukawa, Masayoshi
  • Sakai, Takeo
Type
Published Article
Journal
Microbiology and immunology
Publication Date
Jan 01, 2006
Volume
50
Issue
8
Pages
637–641
Identifiers
PMID: 16924149
Source
Medline
License
Unknown

Abstract

The immunological effects of recombinant feline interferon-omega (rFeIFN-omega ; KT-80, Toray) were examined on administration to healthy dogs. The activities of whole blood cells, macrophages, and natural killer cells were enhanced. Moreover, the whole blood activity was examined when KT-80 was administered to dogs which had been diagnosed as having natural canine parvovirus (CPV) infection. Only some cases in which the activity increased until 3 hr post-administration survived. These results suggest that rFeIFN-omega (KT-80) treatment enhanced the cellular immunity of normal dogs, and could exert significant therapeutic effects on only natural CPV infected dogs with induced continuous immunoenhancement.

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