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Immunological cross-reactivity of the major allergen from perennial ryegrass (Lolium perenne), Lol p I, and the cysteine proteinase, bromelain.

Authors
  • Pike, R N
  • Bagarozzi, D Jr
  • Travis, J
Type
Published Article
Journal
International archives of allergy and immunology
Publication Date
Apr 01, 1997
Volume
112
Issue
4
Pages
412–414
Identifiers
PMID: 9104799
Source
Medline
License
Unknown

Abstract

Antibodies prepared in rabbits against the major allergen from ryegrass (Lolium perenne), Lol p I, cross-reacted with the cysteine proteinase bromelain from pineapple and vice versa. Deglycosylation of the proteins showed that the cross-reaction was based on recognition of the carbohydrate moiety of the allergen, but for bromelain the cross-reaction was most likely due to a combination of factors. The results indicate that the carbohydrate residues from these allergens play an important role in cross-reactions found between them and possibly those from other species.

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